Acetaminophen Safety/Dangers

Acetaminophen is the active ingredient in the popular pain-reliever Tylenol.  According to the FDA, formulations that contain more than 325mg of acetaminophen (some formulations have 500mg or 650mg per pill) have not been shown to relieve pain better than lower doses of the medication; and, in addition, high levels of the drug can cause damage to the liver,  the organ responsible for metabolizing the drug.

Acetaminophen is in over 600 medications, most of which are over the counter, and therefore easily injested in amounts that exceed the daily recommended dosage.  Common OTC brands that contain the drug include Benedryl, Excedrin, Nyquil, Robitussin, Theraflu and Vicks.

For adults the limit is 4,000mg daily, but a total of 3,000 daily is better, and those of lower body weight should stay at the lower end of the range. Drinking alcohol causes the liver to convert more of the acetaminophen taken into toxic byproducts.  When taking the drug, men should have no more than two standard drinks per day, women no more than a single drink of alcohol.



Robert G. Tupac, DDS, FACP, Inc., Diplomate, American Board of Prosthodontics (661) 325-1275 | www.drtupac.com 5060 California Ave., #170, Bakersfield, CA 93309

Grapefruit Juice Drug Interactions

Grapefruit juice and fresh grapefruit have vitamin C and potassium and can be part of a healthy diet.  However, according to Dr. Huang of the Food and Drug Administration, they can interfere with the action of both some prescription and nonprescription drugs.  For example, cholesterol lowering statins (Zocor, Lipitor and Prevachol) have warnings to not have grapefruit while taking them.  Some blood pressure lowering drugs (Nifediac and Afeditab), organ transplant rejection drugs (Sandimmune and Neoral), anti-anxiety drugs (buspar), anti-arrhythmia drugs (Cordarone and Nexterone) and some antihistamines (Allegra) are also affected.  While some medications carry labels regarding grapefruit, you may ask your pharmacist about your particular prescription.  The medication guide included will also provide the necessary information.  If you must avoid grapefruit, read labels of fruit juices to see if it is included.  Seville oranges and tangelos affect the same enzyme as grapefruit juice and are also to be avoided.

Robert G. Tupac, DDS, FACP, Inc., Diplomate, American Board of Prosthodontics (661) 325-1275 | www.drtupac.com 5060 California Ave., #170, Bakersfield, CA 93309