Postmenopausal women who are metabolically healthy but overweight do not have the same increased risk of breast cancer as those who are overweight with high insulin levels. One of the first studies that examined the association between insulin and breast cancer looked at data from 2,830 participants in the Women's Health Initiative, 497 of whom had breast cancer. They compared the insulin sensitivity of those of normal weight and overweight, and used the fasting insulin level to define metabolic health. The study found that metabolically healthy overweight women were not at elevated risk of breast cancer compared with metabolically healthy normal weight women.
Source: CancerRes, 2015: 75(2):270-274
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